He said Elanco is very conscientious about safety (particularly since Interceptor is used by so many people who have MDR1-prone dogs), and even with his advice I still stood there reading the label and agonizing over my decision before I decided to give it a try! Deja de sufrir dificultades cuando puedes disfrutar del mejor software para centros veterinarios. Our are both indoors and outdoors. Isoxazolines like NexGard, Simparica and Bravecto are very important for tick prevention and appear safe to use. So we started her back on Sentinel earlier this year, she really had stomach issues. Prevents: Heartworm, Fleas, Intestinal worms (except tapeworm) Comes as: a meaty chew given once every month (afoxolaner & milbemycin) (357 reviews) Simparica. However, it did make my Collies too itchy. All Rights Reserved. SIMPARICA TRIO tested positive for heartworm disease. But I do think K9 Advantix is a good choice for Collies who arent overly sensitive. ? Thanks again for your time : ), Thank you for pointing that out! How can I prevent my dog from getting ticks? The parasite protections that target multiple parasites with just one topical application or administration of a pill are extremely appealing due to their convenience. 50% Off First Repeat Delivery. Giardia can be passed to and cause diarrhea in humans. Simparica TRIO is a monthly chew with triple protection against the three biggest threats facing our dogs today - fleas and ticks, intestinal worms and deadl. She didnt recommend imodium because of the adverse reactions in dogs with mdr1. Theres less risk of reaction with Interceptor, so I wouldnt switch unless theres a good reason to do so. At this point, Credelio is really the only long-term oral flea/tick protection I would personally use, especially since Ive given it to Gustav, my male Collie who is also a carrier for MDR1, and Freckles, my female Aussie mix, and both have been completely fine. We gave her the first dose in late February and there were no adverse side effects for Sugar. There are other risks involving Ivermectin. Another thing to research and to ask your personal vet about might be potential drug/drug interactions between the Trazadone and Effifax, or whichever parasite preventives you choose to use in the future. Where can I get them tested for MDR1 resistance. I have a unique situation. Because I am only one person, the medication is relatively new, and it has active ingredients that are the same as more well-known medications that have been known to cause issues for many dogs, I didnt feel that I could give it an entirely glowing recommendation. . If you havent yet tried Interceptor for heartworm prevention, I would suggest that for you. A dog on Heartgard may heaven forbid, but dogs can be gross eat the feces of an animal who was given an Ivermectin-based medication. If you have one of those rare dogs who is just going to react to every heartworm medication (fingers and toes crossed thats not the case), then you might want to consider frequent heartworm tests as an alternative to regular heartworm treatment. I went back and edited my comment for consistency. For the treatment and control of tick infestations with Amblyomma americanum (lone star tick) and Ixodes scapularis . collies. Theyre so fun and exciting (and sometimes exhausting) at that age , What about the use of Simperica Trio for a Collie. This is a new extensively tested product now available in Australia that provides optimal protection for your dog. I do not know if my auss is a carrier for the mdr1 gene, and I told the vet about this and they double checked and said that the drugs in simparica trio should be fine for her. . Advantage Multi can be a great product when used with care, and I would expect the same to be true for Advocate. All the available heartworm medications on the market are a variation of what is known clinically as a ML (macrocyclic lactone) compound. And use same collar for a few months. The topical medicines seem to work best with her, but dont do much to keep the tics at bay. Thank you for the reminder! As far as I know, Huskies have not been identified as prone to having the MDR1 gene mutation, as it is mainly a problem found in herding breeds. The product was well tolerated in dogs with a deficient multidrug-resistance-protein 1 (MDR1 -/-). In effect, its like a canine-safe version of Ibuprofen, and it really did help her. ? It was very frightening. IMPORTANT SAFETY INFORMATION: NexGard is for use in . Personally, I would be concerned about missing a daily dose. The manufracturers website lists many different kinds of ticks, and people on this thread talk about using FrontLine for ticks. . Simparica Trio should be given orally once a month at the recommended minimum doses: 0.54 milligrams of sarolaner, 0.011 mlilligrams of moxidectin, and 2.27 milligrams of pyrantel per pound of body weight. (Of course, skin irritation can happen with any topical product.) I had success giving Credelio (active ingredient lotilaner instead of Simparicas sarolaner), but in all honesty I administered that based on my vets recommendation BEFORE I realized the FDA warning also applied to Credelio. Simparica TRIO. However, it would be best to have a veterinarian collect a skin scraping to examine under a microscope and determine whether skin irritation is caused by demodectic or sarcoptic mites, as the causes and treatments differ between the two types. Either way, I certainly dont want to risk it for him again. Whats the best safest flea tick treatment for a collie puppy? SIMPARICA TRIO (sarolaner, moxidectin, and pyrantel chewable tablets) is a flavored, chewable tablet for administration to dogs 8 weeks of age and older. Just checking in to see how you and your pup are doing and if you ended up using Seresto collars or not. Simparica comes as flavored, chewable tablets and is available in a variety of sizes: 5, 10, 20, 40, 80, and 120 mg. 6. Negative reactions such as vomiting, diarrhea, and tremors were only observed at supratherapeutic (higher than recommended) doses. These generics include Tri-Heart Plus, Iverhart Plus, and Nuheart. I like to sprinkle some around the perimeter of my yard and lay an inner circle around the edges of my house which probably looks like Im trying to keep out evil fairies and other fantasy creatures. ( I had to get a different vet for my pup because my current vet couldnt get him in to start his vacines for 2.5 months. If youre going the oral tablet route, Credelio is one I personally feel comfortable with! I found it extremely helpful & educational. Frontline Plus is milder than Frontline Gold, which I wouldnt recommend for the same reason that I dont like recommending Advantix theyre too strong and have a tendency to cause skin reactions. Thank You so much for your quick response Emily!! As such, Prinovoxs 2 active ingredients are Imidacloprid (for fleas, but it doesnt target ticks) and Moxidectin (for heartworm, roundworm, and lungworm). Before I got them home, they went into comas. We actually live in New Hampshire and hike (off-leash) quite frequently. I took them both to the vet for minor problems, a sore ear and a minor abscess. Simparica Trio can be described as a broad-spectrum parasite preventative that offers protection and treatment to dogs. Ive talked to Collie and Aussie owners who absolutely swear by their Seresto collars and others who are livid because they made their dogs neck bald! I personally prefer something gentler as many Collies can have sensitive skin, but it really depends on the dog. Demonstrated 98.9% effectiveness against existing tick infestations in 48 hours . I would actually place it in the caution category, since if a dog who had an active heartworm infection was given diethylcarbamazine (Dimmitrols main ingredient) it could suffer severe side effects and even die. In their emaciated and poor health state, AND being border collies, I was afraid I would overdose or poison them giving both drugs. The neurological problems tied to Simparica scare the shit out . Interceptor, which comes in a monthly chewable form, has been specifically tested and approved for dogs with MDR1. I do remember her cowering and rubbing her back against her crate after we administered anything topical! Im glad you found it helpful. I would say you are right to be concerned, and Ill give some info why. Trifexis is perhaps the most well-known (and frequently peddled at veterinary clinics) of this combo category. You can even scatter some on your dogs bed. Simparica Trio is proven to kill 5 species of ticks. Simparica Trio has the same main ingredient as regular Simparica, plus two added ingredients. Maybe regular Interceptor would be fine since it doesnt contain Praziquantel, but its difficult to say exactly what your dog is reacting to. Another danger often lies in a treated dog being exposed to additional environmental pesticides, which can lead to an accidental overdose. My Collie is double MDR1 mutant. WSU is the leader in identifying drugs that may be dangerous for dogs with the MDR1 mutation and can identify alternative medications and doses. It can be used to destroy bedbugs, cockroaches, ants, and even fleas. In my opinion, this spray is great combined with anything since it has repellent properties and smells delightful. ? I think this is a couple years old. Or is it when given together? I really do not know what to do and get no real input from my Vet. for, I think its brown ticks. Unfortunately, the fleas are fighting back. , Thanks for the reply! We use interceptor for heartworms and was using frontline until she recently started having negative reactions to it. It is also used off-label to control sarcoptic mange and demodectic mange. Either Sentinel or Interceptor are generally considered safe for Collies and can be used to treat demodectic mange. Please let me know how the Wondercide works for you! I actually just updated the section on Seresto collars today with new info and a link to a USA Today article about side effects resulting in seizures and even death. Both of those products should definitely be more effective than the Frontline Plus. On the downside, its efficacy only lasts for about a day. (No judgment if you didnt see that section: I know its a very long article and I expect most people are looking for a quick or specific answer and dont actually read the whole thing ?.) This year she has a very high degree of irritation when applied (I had to wash it off). Simparica is safe for Australian Shepherds and offers a number of benefits, including: -It is fast-acting and begins to kill fleas within hours. I liked your post very informative I have a border collie that I think has the mdr1 gene we are going to have her tested it seems whatever we give her she has a side effect I would like to know if you have any information for pain drugs or natural medicine she has some arthritis and has sprained her leg. Normally I would advise to just listen to your vet, but in this case I think I have to say listen to your instincts also especially since youre the one living with your pet and making the observations. Besides safety, Revolution is an attractive option because of its ease of application (topical squeeze-on tube) and versatility in treating heartworm, fleas, dog ticks, sarcoptic mange, and even ear mites. With complaints rolling in, the company made adjustments to the Ivermectin content in their product, and Heartgard is now advertised to be safe at the recommended dosage. But according to Dr. Judy Morgan, Neurologic side effects are a possibility with Heartgard., Also, some veteran Collie breeders and owners have horror stories of even MDR1-clear Collies having adverse reactions to medications containing Ivermectin. Is this true? Sarolaner is also a component of the combination drug Simparica Trio, which contains sarolaner, moxidectin, and pyrantel. There weren't as many seizures reported as with Nexgard, but it did have several more reported than Bravecto. Unlike many other external parasite treatments that only kill little bloodsuckers after theyve bitten the dog, K9 Advantix claims to kill them on contact. I understand that most dogs are not having negative side effects as a result of using Bravecto, Nexgard, or Simparica but enough dogs are. Rev. Microfilaria and adult heartworm antigen testing. Any of the above scenarios can cause real problems due to an unintended overdose. (Also, bear in mind that the Permethrin in Zodiac Spot On will make it very dangerous, even toxic, to cats, in case you have any.) So called vet and they said topically we should try Parastar Plus. Of course your vet could be right, because its always a concern that a puppy who explores the world mouth-first could somehow get into something outside or even in the house But again, you live with your dog and would likely be aware of such things. Fleas start to bite within 5 minutes. And safe travels to you and Lola in the future. This monthly chewable is recommended for 8 weeks and older dogs, weighing 2.8 lbs or more. This is typically due to a specific genetic mutation (MDR1) that makes them less able to tolerate high doses of ivermectin. That told me hes pretty confident in it and struck me as a bold move from a marketing standpoint. This gave me a great start for research. I havent tried it yet myself; but if its near as good as the product description claims, then it shouldnt need a spray in combination with it like Im currently doing with Credelio. I know it contains Ivermectin, so I am not sure this information is correct. However, as it is the amped-up version of Frontline Plus and contains 3 active ingredients, its always wise to check the application site for adverse skin reactions. The best thing about Seresto is how long it can do its job up to 8 months! After 1 emergency vet visit and a number of consultations with our primary care vet, we took him off simparica. Tap to zoom. After logging in you can close it and return to this page. We recently switched our dogs to a new product called Simparica Trio. Thank you! Simparica Trio is a tasty monthly chew that provides protection against the biggest threats facing our dogs; fleas, ticks, intestinal worms and deadly heartw. We have an MDR1 heterozygous Aussie and this was the best breakdown of the meds we found. However, as with any chemical compounds, caution is advised even with products deemed to be safe. However, not all MLs are created equal, and some are safer than others. Although it would be very hard to determine exactly which component of a combination medication your Collie is reacting to, your girl might be less likely to have a reaction to Interceptor (regular, not Plus), as it only has one active ingredient as opposed to the two active ingredients in Sentinel. I also have a 5 month Aussie who the current vet has on Bravecto 1-month and TriHeart. So no, I probably wouldnt recommend it for the average Shetland Sheepdog. They both have tolerated Bravecto very well.no noticeable side effects. In studies it started killing within four hours, and achieved 100% effectiveness in eight hours. Fleas can lay up to 1300 eggs within 50 days, 4 but Simparica Trio kills them before they can even lay eggs. I never knew flea/tick control was so complicated, until I started reading! Best of luck with your girl. Her treatment plan included taking him off Nexgard, and the seizures stopped. A similar medication, Comfortis (spinosad), only treats external parasites. , I use Advecta 3 because it prevents and kills I have been in the dog Bussiness for over 26 years and used to use frontline bit past few years switched because frontline doesnt prevent .I never had a problem with advecta 3 and hope its safe, As this is a Collie blog and I assume the majority of people who read this post have a Collie, Im just hesitant to recommend it since many Collies have issues with sensitive skin even if theyre clear of MDR1. However, I have to state the disclaimer that even parasite protection products officially labeled safe from an MDR1 standpoint should really be designated safe-ish. Most of these products are chemical compounds, and as such have more potential to cause a reaction than just, well, water. Happy to help! Apparently, it affects certain cats with a certain gene. Any of the -mectins are only safe for MDR1-prone breeds at the recommended dosage. A combination of -mectin in topical and oral form could definitely cause negative reactions if any of your foster puppies have MDR1. We will get her in about 3 weeks. Key Features of Simparica Trio. Approved for use in dogs over the age of 8 weeks and above 2.8 lbs, please note that depending on the pest . (One such knockoff, Pet Armor Plus, is even available at Walmart.). Buy Simparica Trio for Small dogs 5.1-10Kg. Is credelio considered safe when using interceptor? Remember she is fixed. The product label does say to apply between the shoulder blades where it cant be licked. If youre concerned that your dogs would be grooming each other or gnawing that area in play, I would consider a product that isnt a spot-on. (I googled veterinary pharmacists near me and found one locally, but Jacksonville is a huge city.) Doses used for heartworm prevention are safe to use in these breeds of dogs. Simparica TRIO for X-Large Dogs - 88 - 132 lbs - BROWN - 6 tablets (In Stock) $116.95: . I hate to use anything, but also tired of keeping my dogs in a bubble. No treatment-related clinical signs were observed. It makes me nervous since I have seen/read plenty of negative things about bravecto and Im also worried to combine bravecto with interceptor. One thing about Credelio is that it only breaks the flea life cycle at one point (kills adult fleas only after they bite the dog), so you may want to use a natural flea & tick repellent spray to increase its effectiveness. Several clinical trials funded by Zoetis published shortly after drug approval showed impressive results concerning safety and incidence of adverse effects in dogs. However, I think your plan to take the collar on and off was probably the best way to give it a safe trial period. Best of luck to you and Sugar! Unless youre, say, an expat living in China, you can definitely find a better option. As noted in an article by Dog Aware:Advantage Multi, which combines imidacloprid for flea control with moxidectin for heartworm prevention, was found to cause no side effects when applied topically to affected dogs even at 5 times the recommended dose, but ingesting less than half the recommended topical dose caused extreme toxicity leading to coma in four of five dogs.. Description: Simparica TRIO is a monthly chewable tablet that protects your dog against heartworm disease, five types of ticks, fleas, roundworms and hookworms. No one knows yet why some dogs react to isoxazolines like Simparica and others dont, and theres no way to know until its tested on an animal. Simparica Trio proven to block the pathogen that causes Lyme disease by killing deer ticks . If you choose to use Advantage Multi, great care should be taken to only apply the liquid between your dogs neck and shoulder blades, where it cannot be reached by licking. The MDR1 mutation is believed to occur in approximately 50% of Australian Shepherds. According to Dog Aware, most flea and tick control medications have not been found to cause adverse effects when used as directed, but toxicity can occur iftopicalproducts areingested. This is why reading labels is so important. All dogs treated with SIMPARICA TRIO were negative for D. immitis antigen and blood microfilariae at study completion on day 330. The Whole Dog Journal notes that Ivermectin has the most potential for toxicity.. Would this be your recommendation? Ive had success using Burts Bees ear rinse on my dogs. ? My Aussie/Pyrenees mix has had no issues with it, for instance. All I can tell you is that Ive personally used it for years with no adverse reactions, everyone in my local AKC Collie club has also used it without trouble, and Im not aware of negative reports that have reached the news. These four ML compounds (ivermectin, moxidectin, selamectin, and milbemycin oxide) have been officially approved by the FDA (Federal Drug Administration) and tested safe for MDR1 dogs when administered at the recommended preventative dosage. In a laboratory study, the product was well tolerated in dogs with a deficient multidrug-resistance- protein 1 (MDR1 -/-) following single oral administration at 3 times the recommended dose. One person commented that their Collie had irritation at the point of contact, so they recommended checking frequently to make sure the collar is not irritating the skin. I went back to using Frontline Plus for them. Now: $92.79. However, I officially can no longer recommend Seresto collars, since it is now known thatthey have caused seizures and death in dogs and even some reactions in humans who sleep with their dogs in their beds. Safe in avermectin-sensitive collies and dogs with the MDR1 gene; Advantage takes care of fleas at all life stages and is even supposed to kill them on contact, and it also covers lice. Frontline Gold and Frontline Shield. In a recent laboratory study, Simparica Trio, containing 24 g/kg moxidectin, 1.2 mg/kg sarolaner and 5 mg/kg pyrantel, and Heartgard Plus and Interceptor Plus (n = 6) were administered in six consecutive monthly oral doses at the labeled dose rates after receiving an inoculation of 50 ZoeLA strain D. immitis L3 on day 30 [].Dogs were necropsied approximately 9 months post-inoculation and . Ive been accused of being overly cautious when it comes to my dogs, but I admit to being a better safe than sorry kind of person! I recently adopted a Collie puppy who came with a dose of Credelio and Interceptor, which I have in the past successfully used on my other 3 dogs (both Collies and the Aussie mix). Mary. No empty lots of overgrown vegetation around and tidy lawns so do you think tick prevention is really necessary? Super useful research. The active ingredients of SimpleGuard 3 are the same as Vectra 3D: dinotefuran, pyriproxifen, and permethrin. (There are 13 other at-risk breeds including Border Collies, Australian Shepherds, German Shepherds, Shetland Sheepdogs, and Old English Sheepdogs, plus herding breed mixes. Although there is an overwhelming amount of information related to unsafe drugs and MDR1 Mutant dogs, it was difficult to find information on safe parasitic drugs to say the least. I have a new Collie-mix with bi-coloured coat. We need more people like you. My dog has been tested and is mutant/normal (MDR1). Each tablet is formulated to provide minimum dosages of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 g/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). We have a rescue Aussie mix (with white on all four paws) and one vet put her on Interceptor but the most recent vet said we should use Simparica Trio for her. For those who like Advantage but are concerned about ticks on their dogs, the Preventic Tick Collarcan be worn for additional protection. Use ProHeart 6 in dogs 6 months of age or older and ProHeart 12 in dogs 12 months of age or older. Best of luck! Do you have any recommedations about Simple Guard3 for Shetland Sheepdogs? Thank you so much for writing this article!!! That indicates it is a strong chemical compound, so do watch for skin irritation. tratados. I tried Seresto with my girl and she had a seizure. Please keep me updated if you think of it! Simparica TRIO requires a prescription from your veterinarian. Is the Frontline the one listed in the article ok in a multi dog family where there is a risk of one licking it off the other? The vet thought he would be nice and put Advantage Multi on our cats. My thought was to put on a collar in the morning and take it off at night when she will safely be back in the house. Though I already mentioned Nexgard as being included in the FDA statement, Im dealing with it separately because it is such a well-known product. I did some digging, and from what Ive read it sounds like just one report would be considered anecdotal and would not be considered evidence that Seresto could cause seizures, but if there are 2 or more reports then the company might be obliged by the EPA to add a potential seizure warning to its label or possibly to do more clinical safety research. We do eat it! THREE OF THE 8 FEMALES WENT INTO ESTRUS. It was winter. Regardless of the heartworm product you choose, as the Institute of Pharmacology and Toxicology says, treatment of MDR1 mutant dogs with macrocyclic lactones in general requires particular caution. It really boils down to weighing the benefits of medications against the risks from internal parasites. 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