Easily stay on top of the latest nutrition research. Polypodium leucotomos is the deprecated synonym for the tropical fern Phlebodium aureum. followed by specifically-applicable references. J Am Acad Dermatol 2004;51:910-8. 2011;146(2):85-7. 2013;149(8):981-3. Each member of our research team is required to have no conflicts of interest, including with supplement [26] Both studies are limited by no placebo group or blinding, but suggest that Polypodium Leucotomos may protect from PLEs. [16], A hydrophilic extract of Polypodium Leucotomos was first described in 1974. Gonzalez S, Pathak MA. … [12] This resulted in 25% less mutations existing in DNA when measured 2 weeks later. Polypodium leucotomos extract inhibits trans-urocanic acid photoisomerization and photodecomposition. Subacute cutaneous lupus erythematosus: a case report of Polypodium leucotomos as an adjuvant therapy. Med Cutan Ibero.Lat.Am 1982;10(3):203-208. [12] A reduction in inflammation (neutrophil infiltration) was noted with Leucostomos, although no difference existed immediately but a 60% reduction 6 hours after UV irradiation and 68% after 24 hours. Navarro-Blasco, F. J. and Sempere, J. M. Modification of the inflammatory activity of psoriatic arthritis in patients treated with extract of Polipodium leucotomos (Anapsos). Del Pino, Gamboa J., De Sambricio, Guiu F., and Colomo, Gomez C. [Comparative study between 120 mg. of anapsos and a placebo in 37 psoriasis patients]. Calaguala for Psoriasis. 51 No. 1998;37(8):912. Pineiro, Alvarez B. Fernblock® (IFC, Madrid, Spain), an aqueous extract of PL (PLE), is a potent antioxidant ingredient8 with demonstrated photo- and immunoprotective activities against ultraviolet (UV) A and UVB radiations.9,10 It is available in over- View abstract. [2], Calagualine[3] which common to the genus Polypodium[4], The phenolic acids Ferulic, fumaric, vanillic, quinic, caffeic, and chlorogenic acid[5][6][2], 3,4-dihydroxybenzoic acid and 4-hydroxybenzoic acid[6], In vitro testing using Caco-2 cells suggest that some of the anti-oxidative molecules, the benzoic and hydroxycinnamic acids, exhibited great permeability and the authors suggested a possible bioavailability of 70-100%. View abstract. Photodermatol Photoimmunol Photomed 1997;13:50-60. Our evidence-based analysis on polypodium leucotomos features View abstract. © Therapeutic Research Faculty 2020. View abstract. View abstract. Polypodium leucotomos extract in atopic dermatitis: a randomized, double-blind, placebo-controlled, multicenter trial. [28], One of the few controlled trials on the matter note reduced DNA damage secondary to UV(A) radiation, where in measuring levels of the common deletion (CD) of a 4977 base-pair mitochondiral DNA (used as a biomarker for UV(A)-induced damage[31]) where the amount of CD induction at twice the level of UVA required to induce reddening (217% in control relative to baseline) was reduced by 86%, and the induction at thrice the level (760% of baseline) was reduced 61%. View abstract. [23] In regrads to the trials themselves, 250mg of Leucostomos taken thrice a day (750mg total) for 26 weeks was unsuccessful in promoting significant benefits to repigmentation, although it appeared to trend towards benefits. Extant research has shown that extracts of PL possess robust anti-oxidant, photoprotectant, antimutagenic, and immunoregulatory properties. [24], One study assessing the interaction of Polypodium Leucotomos and Polymorphic Light Eruptions (PLEs, itchy rashes from sun exposure; not burns) noted via an open-label study that 30 persons who suffered from these eruptions and took 720-1200mg daily (depending on weight) for 2 weeks had a subset of the group not get the eruptions at all during testing (30%) while the average time to induce eruptions in the rest of the group was extended 34.3%,[25] and a lower dose in 25 persons given 480mg daily noted slight improvement (10-50%) in 36% of the sample and resolution (100% improvement) in 31% of the sample, with 5 persons (20%) not experiencing any benefit. An extract of the fern Polypodium leucotomos (Difur) modulates Th1/Th2 cytokines balance in vitro and appears to exhibit anti-angiogenic activities in vivo: pathogenic relationships and therapeutic implications. 2015;41(8):898-902. View abstract. PLE is a natural extract that comes from a South American fern, and is packed with antioxidants that help skin to naturally protect itself from UV damage. manufacturers, food companies, and industry funders. However, there is evidence to suggest it may have antioxidant and anti-inflammatory properties that are helpful for treating certain skin conditions. It is a natural oral sunscreen derived from a fern, with anti-oxidant and anti-inflammatory properties. 1981;72(1-2):65-68. View abstract. Each member of our research team is required to have no conflicts of interest, including with supplement manufacturers, food companies, and industry funders. Oral Polypodium leucotomos extract decreases ultraviolet-induced damage of human skin. 3 Locally known as “calaguala” in reference to the species and “anapsos” when referring to the extracts, 1 PL was traditionally used for treatment of the inflammatory skin disorders, psoriasis and atopic dermatitis. Our evidence-based analysis on polypodium leucotomos features 33 unique references to scientific papers. In vitro studies on the immunomodulating effects of polypodium leucotomos extract on human leukocyte fractions. Anticancer Res 2000;20:1567-75. The team includes nutrition researchers, registered Polypodium leucotomos (PL) has been used … Comparison of Polypodium leucotomis extract with placebo in 37 cases of psoriasis. Uncontrolled Blood Sugar: How Dangerous Is It? View abstract. Polypodium Leucotomos (Calaguala) is the commonly referred to name of a herb that appears to possess moderately potent protective effects against sun-induced skin damage; may also be an immune booster. Polypodium leucotomos extract can also be used to protect against photochemotherapy -induced skin phototoxicity. Polypodium leucotomos (PL) is a fern from the Polypodiaceae family, which is native to Central and South America. Polypodium leucotomos is used to prevent certain skin problems including sunburn, eczema (atopic dermatitis), psoriasis, vitiligo, and skin cancer.It is also used for other cancers and Alzheimer's disease. 5 November 2019, View abstract. View abstract. Arzneimittelforschung 1995;45:901-4. [2 years personal experience in anapsos treatment of psoriasis in various clinical forms]. Preliminary data for the treatment of hyperpigmentation are promising, and currently, these oral treatments appear safe. Garcia F, Pivel JP, Guerrero A, et al. Most of these, particularly those derived from ultraviolet radiation (UVR) are harmful to the skin, and include cutaneous aging and increased risk of cutaneous diseases, particula Breithaupt AD, Jacob SE. Preventive measures, including photoprotection, are helpful and can be achieved by topical sunscreening agents. J Eur Acad Dermatol Venereol 2007;21(7):942-950. 36 psoriatic patients aged 6-63 with psoriasis for at least 1 month to 24 years of duration were then recruited and given 20 capsules of Polypodium Leucotomos extract (dose of plant not specified) or placebo in a cross-over manner resulted in significant improvements in clinical signs of psoriasis. The aqueous extract of the fern Polypodium leucotomos (PLE), Fernblock® (IFC, Madrid, Spain), has demonstrated antioxidant and photoprotective activities and has been used for the treatment of several pigmentary disorders. Enter your email and we'll keep you on top of the latest nutrition research, supplement myths, and more. 850mg for a 250lb person. [2], 240mg polypodium Leucotomos twice daily for 3 months (480mg daily) has been noted to be associated with less risk of bacterial infections, as athletes with over 20 hours of exercise a week using supplementation had the infection rate in placebo (56% overall, 24% getting pharyngoamygdalitis) reduced (14% and 6%, respectively) over the next eight months of observation. Int J Dermatol 1974;13:276-82. Access detailed breakdowns of the most important scientific studies. https://examine.com/supplements/polypodium-leucotomos/, © 2011-2021 Examine.com Inc | Privacy | Terms of Service | Disclaimer | About Us | Contact Examine.com. Gonzalez S, Pathak MA, Cuevas J, et al. R [9], Supplementation of 720mg anapsos daily for 11 days in otherwise healthy adults appears to cause a trend to increase CD4+ T cells that failed to reach statistical significance. Capella Perez, M. C. and Castells, Rodellas A. We know that oral Polypodium leucotomos protects skin from sun damage, and its photoprotective activity has been assessed in healthy volunteers. 2012;89(4):183-4. 2012;103(7):599-607. [8] Inhibitory effects have also been noted in response to Fasciola hepatica antigen, which triggers a similar Th2 immune response. Ahmed AM, Lopez I, Perese F, et al. [11], A protective trend has also been noted in regards to MMP proteins in vitro, where MMP1-3 were all inhibited in a concentration dependent manner in the range of 0.001-1% Polypodium Leucotomos (PL) and MMP9 between 0.1-1%. Bernd A, Ramirez-Bosca A, Huber H, et al. "Polypodium leucotomos," Examine.com, published on 30 September 2013, last updated on View abstract. [16] A stimulation of TIMP-1 and TIMP-2 was noted to 145-166% and 230-260% of contorl at 0.3% and 1% respectively in normal fibroblasts; thought to be protective. 1981;72(9-10):487-494. [7], The expression of adhesion factors on immune cells appears to be reduced following 11 days of supplementation with 720mg anapsos in otherwise healthy persons, with reductions of CD11b on monocytes and reductions in CD11a, CD11b, and CD18 on lymphocytes. [16], Anti-oxidant properties have been noted in vitro with Polypodum Leucotomos (PL) including Superoxide, Hydroxy, Lipid peroxides, and ROS[17] and it has been hypothesized that these properties reduce UV-induced production of Cyclobutane Pyrimidine Dimers secondary to DNA repair enzymes in skin, leading to less UV-induced DNA mutations. 33 unique references to scientific papers. [3] This study isolated a triterpenoid glycoside from the mashed and dried rhizomes and was named Calagualine in honor of the common name of Polypodium Leucotomos, Calaguala. The team includes nutrition researchers, registered dietitians, physicians, and pharmacists. Ramírez-Bosca A, Zapater P, Betlloch I, et al. 3. View abstract. Polypodium leucotomos (PL) is a fern with origins in Central and South America where it has a historical role in traditional medicine. It contains antioxidants that protect the skin from free radical damage. 1,2 PL belongs to the Polypodiaceae family, genus Phlebodium. 3 … View abstract. Del, PGJ, De, SGF, and Colomo, GC. This page features 33 references. A skin disorder that causes white patches to develop on the skin (vitiligo). View abstract. [16] The IC50 values of PL on MMP1, 2, 3, and 9 were 0.5, 0.05, 0.1, and 0.5% respectively. View abstract. Examine.com and its Editors do not advocate nutritional supplementation over proper medical advice or treatment and this sentiment will never be expressed through pages hosted under Examine.com. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. PUVA is a form of light therapy used to. [25] Another study using Polypodium at 480mg daily (based off 7.5mg/kg bodyweight) with a 15 day 'loading' period before sun exposure noted that 73.68% of the 57 subjects (53 of whom experienced PLEs) reported benefit, with 43.86% reporting benefit relative to their baseline status (subjective rating) while 29.82% reported no change relative to before exposure. Decrease of ultraviolet A light-induced "common deletion" in healthy volunteers after oral Polypodium leucotomos extract supplement in a randomized clinical trial. Middelkamp-Hup MA, Pathak MA, Parrado C, et al. Research analysis led by Kamal Patel. [2], One study using 0.25mg/kg Polypodium Leukotomos (PL) hydrosoluble extract (intramuscular injections) for 7 days leading up to sugery noted that PL was able to normalize a trauma-induced shift in T-cell morphology and attenuate changes in select cytokines (IL-6 and IL-12, but not IL-1, 2, or 4) that are seen as indicative of this shift of T-cell morphology. [21], One study has noted that Polypodium Leucotomos was able to stimulate collagen expression (type I, II, and V) at 1% concentrations, as well as the Type I collagen promoter. A randomized, double-blinded, placebo-controlled trial of oral Polypodium leucotomos extract as an adjunct to sunscreen in the treatment of melasma. 12. © 2005 - 2021 WebMD LLC. Actas Dermosifiliogr. [27], Another study in persons with Phototype II or III skin (non-pale white persons) exposed to UV rays who did not otherwise have skin conditions noted that 7.5mg/kg Polypodium Leucotomos taken the night previous to testing was able to delay the rate of which the skin reddens (erythema) alongside a reduction in mast cell infiltration. HELIOCARE PUREWHITE RADIANCE MAX 240 From Polypodium leucotomos to Fernblock® Innovation - An exclusive combination of skin whitening ingredients for the ultimate skin whitening pills. Middelkamp-Hup MA, Pathak MA, Parrado C, et al. Be sure to follow relevant directions on product labels and consult your, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Coronavirus in Context: Interviews With Experts, Sign Up to Receive Our Free Coroanvirus Newsletter. But other research suggests that it might have a small effect when used with, Skin damage caused by PUVA therapy. [12] p53 is a well known tumor suppressor gene,[13] and its activation may be the mechanism underlying genomic protection and anti-inflammatory effects. Methods Find.Exp Clin Pharmacol 2000;22(7):585-594. dietitians, physicians, and pharmacists. Click here to see the full set of references J Am Acad Dermatol. J Am Acad Dermatol 2004;50:41-9. Gonzalez S, Alcaraz MV, Cuevas J, et al. Psoriasis is a chronic type of skin disease characterized by the appearance of thick, dry, red patches of skin in several areas of the body. Become an Examine Member to get access to all of the latest nutrition research: Polypodium Leucotomos is the more common and taxonomically incorrect name for the herb known as Phlebodium aureum, in the Polypodiaceae family but the Phlebodium genus; this herb is commonly referred to as Calaguala or Golden Serpent Fern and is commonly grown in Central America[1] and extracts from this plant are called Anapsos. Polypodium leucotomos is a fern from Central and South America. A new agent (hydrophilic fraction of polypodium leucotomos) for management of psoriasis. Int J Dermatol 1989;28:479. [2], Anapsos appeared to stimulate NK cells in vitro at a concentration of 150µg/mL, yet oral supplementation at 720mg for 11 days has failed to significantly increase NK cell count in otherwise healthy adults (instead showing a positive trend). View abstract. Here's a closer look at the research: Orally administered Polypodium leucotomos extract decreases psoralen-UVA-induced phototoxicity, pigmentation, and damage of human skin. Clinical trials have been performed in people with skin types II to IV and results show that polypodium leucotomos extract provides significant protection of the skin against UV radiation. Allergol.Immunopathol.(Madr.) ... Polypodium leucotomos 500mg. [12] Interestingly, oral ingestion of Polypodium may also protect against UV(B) induced immunosuppression during prolonged irradiation. It is a begenin pathology but very disabling for those who suffer from it: the skin is itchy and the red patches are particularly unsightly. Rodríguez-Yanes E, Cuevas J, González S, Mallol J. View abstract. Mohammad A. Vitiligo repigmentation with Anapsos (Polypodium leucotomos). We have a strict editorial process. [12], One study using 300mg/kg oral ingestion of Leucostomos has noted a suppression of COX2 induction in response to radiation (70%), which was normalized within 48 hours (and may be downstream to induction of p53,[19] also noted in this study). [22], A Cochrane systemic review on possible herbal compounds to benefit Vitilgo, which assessed Polypodium Leucostomos, failed to find sufficient evidence for a meta-analysis to support any benefit to Vitilgo. 1987;15(4):185-189. 98 ($0.48/Count) Auriemma M, Di Nicola M, Gonzalez S, Piaserico S, Capo A, Amerio P. Polypodium leucotomos supplementation in the treatment of scalp actinic keratosis: could it improve the efficacy of photodynamic therapy? Photodermatol Photoimmunol Photomed 1996;12:45-56. Journal of Photochemistry and Photobiology, 82, 173-179: Capote R. et al. Oral administration of Polypodium leucotomos delays skin tumor development and increases epidermal p53 expression and the anti-oxidant status of UV-irradiated hairless mice. Actas Dermosifiliogr. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. [20], These may also be downstream of p53 activation, known to suppress inflammatory responses,[14] and other studies have noted similar antiinflammatory actions when measuring serum TNF-α and iNOS expression. Jimenez, D., Naranjo, R., Doblare, E., Munoz, C., and Vargas, J. F. Anapsos, an antipsoriatic drug, in atopic dermatitis. [28] Although a preservation of Langerhans cells (related to the immune system) has been noted previously associated with Polypodium Leucotomos in animals[29] and humans,[30] this study merely noted a trend. Mercadal, Peyri O. and Maesci, Cappitanio F. [Preliminary communication on the treatment of psoriasis with anapsos]. If using any pharmaceuticals or drugs given to you by a doctor or received with a prescription, you must consult with the doctor in question or an equally qualified Health Care Professional prior to using any nutritional supplementation. Br J Rheumatol. Polypodium leucotomos extract (PLE) has been shown in laboratory, animal, and clinical studies to serve as a potent antioxidant that helps mitigate UV-induced damage by scavenging free radicals and reactive oxygen species. Extensive PUVA treatment results in premature ageing changes in the skin (increased dryness, … Buy Heliocare Skin Care Dietary Supplement: 240mg Polypodium Leucotomos Extract Pills - All Natural, Antioxidant Rich Formula Derived from Nature with Fernblock and PLE Technology - 60 Veggie Capsules on Amazon.com FREE SHIPPING on qualified orders We currently have no information for POLYPODIUM LEUCOTOMOS overview. Actas Dermosifiliogr. Composition: DualNA Cell Complex Powder (24 Vials) DualNA Glutathione 70,000mg; DualNA FGF (Fibroblast Growth Factor) 3,500mg; DualNA Pro-Coenzyme Q10 8,000mg All rights reserved. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. All factual claims are followed by specifically-applicable references. Dark skin patches on the face (melasma). Polypodium leucotomos supplementation has shown benefit in humans with oral supplementation of 7.5mg/kg for skin health (dose based on weight due to correlating with the amount of skin somebody has); this results in a dosage of:. The underground “runners” (rhizomes) are used for medicine. OTHER NAME(S): Anapsos, Calaguala, Difur, Fern, Fougère, P. Leucotomos, PL, PLE, Polypodium. Br J Clin Pharmacol 1997;43:85-9. Examine.com does not assume liability for any actions undertaken after visiting these pages, and does not assume liability if one misuses supplements. A., Pichel, V., Perez, P., Laredo, M., Corzo, D., Zas, R., Fernandez-Novoa, L., Sempere, J. M., Diaz, J., and Cacabelos, R. Double-blind, randomized, placebo-controlled pilot study with anapsos in senile dementia: effects on cognition, brain bioelectrical activity and cerebral hemodynamics. Polypodium leucotomies protect the skin from the sun with anti-oxidant, cancer prevention and photo prevention activities. Cutis. 33 unique references to scientific papers. Phenolic components and antioxidant activity of Fernblock, an aqueous extract of the aerial parts of the fern Polypodium leucotomos. View abstract. The tablets help the people to leave the idea of adding the heavy layer of cream or lotion over the skin. Polypodium Leucotomos: Polypodium leucotomos is a tropical fern. G Ital Dermatol Venereol. It contains compounds that may fight inflammation and … The underground "runners" (rhizomes) of the plant are used for medicine. Fernblock® Innovation, premise of all Heliocare® items comes from institutionalized Cantabria Labs extric If undergoing medical therapies, then consult with your respective Therapist or Health Care Professional about possible interactions between your Treatment, any Pharmaceuticals or Drugs being given, and possible nutritional supplements or practices hosted on Examine.com. Keep in mind that natural products are not always necessarily safe and dosages can be important. The aim of this study was to evaluate the efficacy and safety of oral PLE in the treatment of melasma in Asian patients. This page is regularly updated, to include the most recently available clinical trial evidence. [12] Similar reductions in infiltration have been noted with macrophages, but these reductions persist at 24 hours (48%), 48 hours, (51%) and even 72 hours after UV irradiation (41%). Examine.com is intended to be used for educational and information purposes only. Heliocare Skin Care Dietary Supplement: 240mg Polypodium Leucotomos Extract Pills - Antioxidant Rich Formula with Fernblock and PLE Technology - 60 Veggie Capsules 4.6 out of 5 stars 819 $28.98 $ 28 . [Double-blind study using "anapsos" 120 mg. in the treatment of psoriasis]. Get a monthly report summarizing studies in the health categories that matter specifically to you. [5], Supplementation of 360-720mg of anapsos for a period of 28 days in adults with senile dementia, supplementation of the lower dose only was able to improve cognition (assessed via ADAS-Cog) and improve cerebral blood flow. We have a strict editorial process. Polypodium leucotomos is a fern from Central America. There is evidence that taking Polypodium leucotomos extract or using a lotion containing Polypodium leucotomos before sun exposure can reduce reddening of the skin and signs of skin damage. Caccialanza M, Recalcati S, Piccinno R. Oral polypodium leucotomos extract photoprotective activity in 57 patients with idiopathic photodermatoses. Exp Dermatol 2014;23:526-8. Goh CL, Chuah SY, Tien S, Thng G, Vitale MA, Delgado-Rubin A. Double-blind, placebo-controlled trial to evaluate the effectiveness of Polypodium leucotomos extract in the treatment of melasma in Asian skin: a pilot study. 2012;66(1):58-62. Inhibition of ultraviolet-induced formation of reactive oxygen species, lipid peroxidation, erythema and skin photosensitization by polypodium leucotomos. View abstract. Med Cutan Iber Lat Am 1982;10:203-208. J Am Acad Dermatol. This information may not fit your specific health circumstances. There is evidence that taking Polypodium leucotomos extract might increase skin color on some, but not all, body areas in people with vitiligo. Click here Polypodium leucotomos: The Latest Oral Sunscreen on the Block PL or anapsos, a synonym, is a South American species of fern in the family Polypodiaceae. Vitamins and Supplements to Avoid with Hepatitis C. Quiz: What Do You Know About Vitamin B12 Deficiency? Unlock information on 400+ supplements and 600+ health topics. Sunburn. Sempere JM, Rodrigo C, Campos A, et al. Information from this source is evidence-based and objective, and without commercial influence. Med Cutan Ibero.Lat.Am 1983;11(1):65-72. 500mg for a 150lb person. Dermatol Surg. Solar radiation in the ultraviolet (UV), visible (VIS), and infrared (IR) ranges produces different biological effects in humans. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. All factual claims are View abstract. Alvarez, X. Padilla HC, Lainez H, Pacheco JA. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. Some early research suggests that taking Polypodium leucotomos doesn't help to lighten dark skin patches from melasma. At this time there is not enough scientific information to determine an appropriate range of doses for Polypodium leucotomos. View abstract. In this article, we will briefly discuss its mechanisms of action as well as review its use in the treatment of dermatologic diseases. These plaques appear in flare-ups: they appear and disappear spontaneously. 2006: Oral Polypodium leucotomos extract decreases ultraviolet-induced damage of human skin. Methods Find Exp Clin Pharmacol 2006;28:157-60. Results: Multiple systemic therapies for skin lightening exist including oral carotenoids, glutathione, melatonin, Polypodium leucotomos hydrophilic extract, procyanidin, and tranexamic acid. Polypodium leucotomos (PL) has been used … Sunburn, immune suppression, photoaging, and skin cancers result from uncontrolled overexposure of human skin to solar ultraviolet radiation (UVR). Polypodium leucotomos Zinc Vitamin C Description Oscreen tablet is oral sunscreen tablet with the unique combination. 2010;62(3):511-3. Middelkamp-Hup, M. A., Bos, J. D., Rius-Diaz, F., Gonzalez, S., and Westerhof, W. Treatment of vitiligo vulgaris with narrow-band UVB and oral Polypodium leucotomos extract: a randomized double-blind placebo-controlled study. Examine.com and its Editors do not ensure that unforeseen side effects will not occur even at the proper dosages, and thereby does not assume liability for any side effects from supplements or practices hosted under the domain of Examine.com. [3], One multicenter phase IV trial in youth using corticosteroids/histamines to suppress symptoms of atopic dermatisis noted that 240-480mg Polypodium daily for a period of noted that usage of corticosteroids (to be used when inflammation was deemed excessive) was not significantly changed in treatment relative to placebo but that histamine usage (used in response to itching) was reduced from 13.6% of days to 4.5%. WebMD does not provide medical advice, diagnosis or treatment. It has also been shown to be an effective treatment in patients suffering from several cutaneous diseases such as vitiligo , psoriasis , idiopathic photodermatosis , atopic dermatitis , and melasma, by adding extra protection when UV radiation exposure cannot be … [10], Multiple studies note an enhancement of p53 expression in skin cells following the combination of UV radiation and PL ingestion (300mg/kg) relative to UV radiation alone,[11][12] the degree of induction being 2-4 fold higher than irradiated control.